Wednesday, March 26, 2014

Cereal flake size influences calorie intake

Cereal flake size influences calorie intake

 IMAGE: The researchers tested the influence of food volume on calorie intake by systematically reducing the flake size of a breakfast cereal with a rolling pin so that the cereal was...
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People eat more breakfast cereal, by weight, when flake size is reduced, according to Penn State researchers, who showed that when flakes are reduced by crushing, people pour a smaller volume of cereal into their bowls, but still take a greater amount by weight and calories.
"People have a really hard time judging appropriate portions," said Barbara Rolls, professor of nutritional sciences and Helen A. Guthrie Chair in Nutrition. "On top of that you have these huge variations in volume that are due to the physical characteristics of foods, such as the size of individual pieces, aeration and how things pile up in a bowl. That adds another dimension to the difficulty of knowing how much to take and eat."
According to Rolls, national dietary guidelines define recommended amounts of most food groups in terms of measures of volume such as cups.
"This can be a problem because, for most foods, the recommended amounts have not been adjusted for variations in physical properties that affect volume, such as aeration, cooking, and the size and shape of individual pieces." Rolls said. "The food weight and energy required to fill a given volume can vary, and this variation in the energy content of recommended amounts could be a challenge to the maintenance of energy balance."
The researchers tested the influence of food volume on calorie intake by systematically reducing the flake size of a breakfast cereal with a rolling pin so that the cereal was more compact and the same weight filled a smaller volume. In a crossover design, the team recruited 41 adults to eat cereal for breakfast once a week for four weeks. The cereal was either standard wheat flakes or the same cereal crushed to reduce the volume to 80 percent, 60 percent or 40 percent of the standard. The researchers provided a constant weight of cereal in an opaque container and participants poured the amount they wanted into a bowl, added fat-free milk and non-calorie sweetener as desired and consumed as much as they wanted.
The researchers reported their results in the current issue of the Journal of the Academy of Nutrition and Dietetics.
The research showed that as flake size was reduced, subjects poured a smaller volume of cereal, but still took a significantly greater amount by weight and energy content. Despite these differences, subjects estimated that they had taken a similar number of calories of all versions of the cereal. They ate most of the cereal they took, so as flake size was reduced, breakfast energy intake increased.
"When faced with decreasing volumes of cereal, the people took less cereal," Rolls said. "Yet, even though they thought they were taking the same number of calories, they ended up significantly overeating."
 IMAGE: The researchers crushed the cereal to reduce the volume to 80 percent, 60 percent or 40 percent of the standard.
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According to Rolls, the findings of the study have implications for both portion selection and dietary advice. National guidelines for most food groups define recommended amounts in terms of volume, such as cups, but only a few adjustments are made for differences in food volume stemming from physical properties of food, she said. Rolls's 2012 book "The Ultimate Volumetrics Diet," offers readers practical tips on how to use variations in food volume to manage their calories and body weight. The book is based on her decades of research, which shows that lowering the calorie density -- or calories per bite -- of food can help people feel full while eating fewer calories.
"There are a lot of variations in food volume that we're not given much advice about," Rolls said. "Our research shows clearly that, without us even knowing it, these variations can have a big impact on how much we're eating. For cereals with small pieces, the recommended serving size should be reduced to account for the uncharacteristically low volume, in the same way that the recommended serving size is increased for voluminous foods, such as puffed cereals and leafy greens."
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Other authors on the paper include Jennifer Meengs, laboratory manager in nutritional sciences, and Liane Roe, research nutritionist in nutritional sciences.
The National Institutes of Health supported this research.

Monday, February 10, 2014

Ketones - Part 5 - DKA

Ketones - Part 5 - DKA - Click on this link for a descriptive image



diabetic ketoacidosis

Wednesday, February 5, 2014

Ketones - part 1

Ketones - part 1 Click to read more -  The timing of reading - Check the vial - it can vary from 5 to 30 seconds

Thursday, January 30, 2014

Tuesday, January 14, 2014

Nutritional Value of Meals at Full-service Restaurant Chains

Nutritional Value of Meals at Full-service Restaurant Chains

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and see below for an unrelated info

DiaVacs's Immunotherapy Product for Treatment of Type 1 Diabetes Receives Orphan Drug Status Designation from FDA

EDGEWATER, N.J.Jan. 6, 2014 /PRNewswire/ -- DiaVacs, Inc. announced today that the Office of Orphan Products Development of the Food and Drug Administration (FDA) has granted orphan drug designation for the company's type 1 diabetes mellitus (T1DM) therapy. DV-0100 is proprietary, novel and safe. The therapy halt's the body's autoimmune reaction against the pancreatic islet cells which are responsible for producing insulin, thus allowing them to produce insulin normally and reversing the trajectory of the disease. Orphan designation qualifies DV-0100 for seven years of marketing exclusivity in the U.S. if the company is the first to obtain marketing approval for this product in T1DM and also qualifies the company for certain tax credits and waivers for prescription drug user fees.
"The granting of this orphan drug designation represents a key milestone for the company," commented Dr. Haro Hartounian, CEO of DiaVacs. "We are excited by the promise that DV-0100 showed in our Phase 1 clinical trial and look forward to assessing its therapeutic potential in the ongoing Phase 2 clinical trial for this indication."
The proprietary DiaVacs technology is derived from a deep understanding of the human immune system. The company has perfected the immunology and technology to take a patient's own dendritic cells (DC) from their blood, modify the cells through the use of small interfering oligonucleotides, and vaccinate the patient by injection of these modified cells under the skin with a small needle. The cells are absorbed, trafficked to the pancreatic lymph nodes, and thereby induce tolerance. This therapy has been shown to be safe and effective in animal models of T1DM, and evidenced no safety signals in human Phase 1 trials in patients with established type 1 diabetes for five years or longer. In some patients in our Phase 1 human trial, production of endogenous insulin was measured, even after 10 years of disease. The FDA has approved, and the company has initiated, a Phase 2 human trial.

Thursday, January 9, 2014

Appropriate nutrient supplementation in celiac disease.

Reduced levels of iron, folate, vitamin B12, vitamin D, zinc, and magnesium are common in untreated celiac disease (CD) patients probably due to loss of brush border proteins and enzymes needed for the absorption of these nutrients. In the majority of patients, removal of gluten from the diet leads to histological recovery and normalization of iron, vitamin, and mineral levels. Iron deficiency anemia is the most common extra-intestinal sign of CD and usually resolves with adherence to a gluten-free diet. However, deficiencies of both folate and vitamin B12 may persist in some patients on a gluten-free diet, thus requiring vitamin supplementation to improve subjective health status. Similarly, exclusion of gluten from the diet does not always normalize bone mineral density; in these cases, supplementation of vitamin D and calcium is recommended. Resolution of mucosal inflammation may not be sufficient to abrogate magnesium deficiency. Since gluten-free cereal products have a lower magnesium content as compared with gluten-containing counterparts, a magnesium-enriched diet should be encouraged in CD patients. In this article we discuss the frequency and clinical relevance of nutrient deficiency in CD and whether and when nutrient supplementation is needed.
 2013 Dec;45(8):522-31. doi: 10.3109/07853890.2013.849383. Epub 2013 Nov 7.